Strategies for Natural Product Discovery by Unlocking Cryptic Biosynthetic Gene Clusters in Fungi
نویسندگان
چکیده
Recent advancements in genome sequencing and bioinformatic analysis of fungal genomes have revealed that fungi possess cryptic or silent biosynthetic gene clusters (BGCs). This discovery suggests our understanding the universe secondary metabolomes is limited. In this review, we summarize recent strategies for activating BGCs fungi, identify metabolites, highlight their biological activities. We also briefly discuss isolation purification methods these compounds. Our focus on genetics-dependent genetics-independent approaches fungi. Using discussed here, natural products hold significant potential as a source new drug candidates.
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ژورنال
عنوان ژورنال: Separations
سال: 2023
ISSN: ['2297-8739']
DOI: https://doi.org/10.3390/separations10060333